The CD7 antibody (MSVA-007R) is a recombinant rabbit monoclonal antibody designed for immunohistochemical (IHC) detection of CD7, a T-cell surface glycoprotein and early T-cell maturation marker, in human tissues. CD7 is a transmembrane costimulatory protein expressed on thymocytes, most mature peripheral T cells, natural killer (NK) cells, and pluripotent bone marrow stem cells. It plays a role in T-cell development and lymphoid interactions, although its precise function remains under investigation.
This antibody produces strong, predominantly membranous staining in T-lymphocytes, allowing clear visualization of T-cell populations in tonsil, colon, and other lymphoid tissues, while normal epithelial structures remain negative.
Product Highlights
Target: CD7 (T-cell surface antigen, GP40, Leu9, p41)
Localization: Membranous (T-lymphocytes)
Application: IHC (FFPE)
Recommended dilution: 1:100–1:200
Host: Recombinant rabbit monoclonal
Reactivity: Human
Expression & Research Relevance
Normal tissues: Strong membranous staining in T-cells of the tonsil interfollicular zones, germinal centers, and intraepithelial T-cells of the colon; most epithelial tissues are negative
Bone marrow: Some T-lymphocytes stain positive
Cancer tissues: Frequently expressed in T-cell acute lymphoblastic leukemia (T-ALL) and mature T-cell lymphomas; occasionally observed in AML, CML, and select solid tumors
Research applications: Useful for T-cell characterization, lymphoma research, and immune profiling
Validation
MSVA-007R specificity is supported by consistent staining of known CD7-positive T-cell populations and absence of non-specific staining in epithelial cells or tissues prone to IHC background. Findings are in line with published RNA and protein expression data from the Human Protein Atlas (HPA).
Research Use Only
For research use only. Not intended for diagnostic or therapeutic applications.
